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Featured Case Study

How the Contract Vivarium Enabled an Emerging Biotech to Improve Results vs. a CRO

By moving studies from a CRO to Mispro, an emerging biotech was able to hit critical milestones with valid data, winning them a major collaboration deal.

"Mispro’s facility, services and expertise has been a key factor in the success we’ve had with our in vivo program."

The Client

A pharmaceutical drug development company in the preclinical trial phase of developing novel therapies based on CRISPR gene editing technology.

The Challenge

The client outsourced in vivo rodent studies to a contract research organization (CRO), leading to unsatisfactory results. The CRO failed to meet their needs, resulting in poor outcomes, including delays and high failure rates.

The high failure rates in the preclinical testing were attributed to user error at the CRO due to lack of experience in the biomethodology essential to the development of the clients’ novel therapies. The long delays and high failure rates resulted in excessive budget spend and missed target dates.

Building their own vivarium was cost-prohibitive and would set their schedule back at least a year. Outsourcing to another contract research organization and hoping for better results was risky.

The Results

By moving their studies to Mispro and regaining control over their science, the client achieved dramatically improved results in each phase of their program. The client was able to track significant improvements in conducting their studies in Mispro’s research environment versus outsourcing to a CRO.

6X Increase in study volume: The client’s teams were able to work faster and more efficiently in Mispro’s contract vivarium, accelerating their timelines at every stage of research and increasing the study volume 6x.

50% reduction in costs: Mispro’s pricing structure and value benefits allowed the client to decrease overall costs by 50%, saving more of their budget for research.

70% reduction in failure rates: Mispro’s full service vivarium support resulted in a 70% reduction in failure to replicate preclinical in vitro proof of concept (PoC) trials during the client’s preclinical in vivo trials.

Case Study Results

  • 6X Increase in study volume
  • 50% reduction in costs
  • 70% reduction in failure rates
  • $20M collaboration deal as a result

News & Resources

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"Mispro’s facilities and services are a great resource for early-stage biotechs, offering them an affordable and reliable choice for in vivo studies that accelerates timelines and enables impactful science."

Ed Field

President, BioLabs

"We have outsourced our in vivo proof-of-concept studies in the past and the data was variable and lacked critical observations. Bringing our work in house in Mispro’s expertly run research environment has allowed for better controls and cleaner results."

Platform Biotechnology Company

Preclinical Translational Medicine Scientist

"Mispro has carefully and expertly designed both its facility and supporting services to enable researchers to conduct studies with precision and confidence. We’ve doubled our in vivo capacity in less than a year as a result of our success in Mispro’s research environment."

Shannon Shields

Group Leader, GenEdit

"The convenience of working in Mispro’s vivarium has been instrumental to our preclinical program. From the close proximity of our lab to their state-of-the-art research facility, to their unmatched animal care and compliance services, Mispro has played a vital role in our success."

Clinical Stage Pharma Company

Senior Associate Scientist